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Best Mushrooms for Anxiety: Fungi for Calming the Mind & Body

Best Mushrooms for Anxiety: Fungi for Calming the Mind & Body
Written by Real Mushrooms - Updated: June 18, 2024

Functional fungi can help balance the immune system, help with sleep, and give you a boost of energy. But what are the best mushrooms for anxiety and can mushroom supplements be calming to a worried mind?

“Stressed out” seems to be an all too common sentiment these days. If you find that you feel dread and apprehension even when there is no apparent stressor, you may have anxiety (1).

Left untreated, anxiety just breeds more of the same. As a result, anxiety may also increase your risk of chronic health conditions, due to its impact on the autonomic nervous system (2).

The good news is you can do something about your anxiety. There are a variety of tools and methods that can help, and research suggests adaptogens, like functional mushrooms, can play a big role. Read on as we dive into how functional mushrooms can help anxiety and the top 3 we recommend.

What’s in this article:

  1. How Do Mushrooms Help Anxiety?
  2. Best Mushrooms for Anxiety
  3. How to Use Mushrooms for Anxiety

How Do Mushrooms Help Anxiety?

Let’s take a look at the 3 main ways functional mushrooms help anxiety.

Mushrooms and Neurogenesis

It was once a common assumption that the human brain stops developing once you reach your mid-20s. Essentially, the assumption was that the neurons you had at birth were what you were stuck with for life (3).

Scientists began challenging this dogma in the 1960s. And recent research confirms that a healthy adult brain continues making new neurons (4).

The process of generating new neurons — called neurogenesis — in the adult human brain appears to be limited to your hippocampus. This part of your brain is responsible for learning, memory, and emotions (5).

In fact, about 700 new neurons are added to your hippocampus every day (6).

The birth of new neurons appears to be connected to neuroplasticity. This is also known as your brain’s ability to be reshaped, adapt, and make new neural connections.

One neurobiology concept states that “neurons that fire together, wire together.” Every time you experience anxiety in response to something new, the connection between that trigger and your anxiety gets stronger (7).

If neuroplasticity allows your neurons to create unwanted patterns, it may also be possible to harness its power to improve them.

Unfortunately, several intrinsic and extrinsic factors can affect neurogenesis, including (7,8):

  • Diet
  • Aging
  • Brain injury
  • Brain inflammation
  • Oxidative stress
  • Stress
  • Lack of exercise
  • Opioid addiction

Impaired neurogenesis in adults has been associated with neurological conditions (8).

Laboratory and animal studies are beginning to show that adaptogens can support neurogenesis (8,9,10). A healthy lifestyle supported by adaptogens like healthy mushrooms may help lift your mood and reduce anxiety.

Mushrooms for neurogenesis
Adaptogens such as functional mushrooms have demonstrated in recent studies that they can support the growth of new brain cells (neurogenesis) in the hippocampus. This part of your brain is responsible for learning, memory, and emotions.

Mushrooms and Neurotransmitters

You might have heard that mental health disorders are caused by chemical imbalances in the brain. But what does that mean?

It means that the balance of the chemical messengers in your brain, known as neurotransmitters, has been disrupted.

Your brain is home to hundreds of different types of neurotransmitters. In the past, anxiety research has focused on the neurotransmitter γ-aminobutyric acid (GABA). But we now know several other neurotransmitters play a role, including (11,12):

  • Serotonin
  • Dopamine
  • Opioid peptides
  • Endocannabinoids
  • Neuropeptide Y
  • Oxytocin
  • Acetylcholine
  • Corticotropin-releasing hormone

Anxiety, then, is not a hard-wired defect in your brain. Rather, it may be a deficit or overabundance of the chemical messengers that control your emotional responses.

Mushrooms may increase your resistance to stress by acting in a similar manner to some neurotransmitters. The exact mechanism by which this occurs has not yet been identified. But it is presumed that some adaptogens act via the pathway that mediates your body’s stress response (13).

Adaptogens are also mild stressors. Some researchers believe repeated exposure to mild or low doses of stress can increase your resistance to future stress exposure (13). This concept is also evident in the action of plant-based adaptogens such as green tea and rhodiola.

Mushrooms and Inflammation

A key protective mechanism exerted by mushrooms is their ability to regulate your immune system. This is how they help your body maintain an optimal, balanced state.

These properties are also critical for your body’s healthy inflammatory response.

Inflammation is a natural part of your immune system to damaging factors, such as injuries or harmful chemicals. This essential, temporary response leads to many symptoms you’re already familiar with — fever, pain, swelling, etc.

When your body’s inflammatory response goes awry, chronic inflammation can set in. The infiltration of inflammatory cells into the tissue site can lead to further tissue damage (14). Chronic inflammation may also be a mechanism for anxiety disorders (15,16,17,18).

Mushrooms are rich sources of compounds that support a healthy inflammation response, such as (19):

  • Polysaccharides (e.g., beta-glucans)
  • Fatty acids
  • Carotenoids
  • Vitamins
  • Minerals
  • Mycosteroids
  • Phenolic and indolic compounds
  • Ergothioneine

Some experts believe adaptogens like mushrooms could help counteract the “weight” of the stressor. As a result, they make it less likely that the body will fall into a stressed state (20).

Mushrooms for inflammation and anxiety
Several recent studies show that chronic inflammation may be a factor behind anxiety. Using functional mushrooms can support a health inflammation response, to keep your body and mind in balance.

Best Mushrooms for Anxiety

Mushroom consumption in general appears to be linked to lower odds of mood disorders (21). Because depression and anxiety often appear together, mushrooms may support an overall positive mood.

So which mushrooms help with anxiety? Here are our top 3 best mushrooms for anxiety.

Reishi for Anxiety

Reishi’s (genus Ganoderma) great reputation dates back thousands of years in many Asian cultures (22). Today, the most common reishi you’ll find is Ganoderma lucidum a.k.a. lingzhi. Traditional Chinese medicine (TCM) practitioners use reishi (also called lingzhi) to (23):

  • Replenish Qi (the body’s vital energy)
  • Calm the mind
  • Influence the heart, lungs, liver, and kidney channels
  • Decrease cough and chest discomfort

Reishi’s health benefits are so revered that TCM physicians still call it “the mushroom of immortality” (24).

But how well does this king of mushrooms hold its own against modern scrutiny?

It may not be able to grant you immortality, but scientists have confirmed a myriad of benefits that could contribute to a long, healthy life. So far, over 400 different compounds have been identified that may assist the body in various ways. They include (25):

  • Polysaccharides
  • Triterpenoids
  • Steroids
  • Fatty acids
  • Amino acids
  • Proteins
  • Nucleosides
  • Alkaloids

Research suggests that some of these compounds have brain-protecting properties. In one study, scientists investigated the potential of reishi to alleviate anxiety in mice. The mice that were given reishi extracts were able to stay much longer in the elevated plus maze (EPM). EPM is a commonly used measure of rodent anxiety (26).

In another mouse study, reishi extract showed a sedative effect on the central nervous system. Researchers observed that mice given reishi extract exhibited behaviors indicating less anxiety compared to those who weren’t given any (27).

Reishi for sleep and anxiety
Reishi (Ganoderma lucidum a.k.a. lingzhi) has an ancient reputation for being able to calm the mind. Modern animal studies are confirming its potential for alleviating worry and supporting longer sleep time.

Reishi and Chronic Illness Fatigue

Living with chronic illness can trigger anxiety and depression (28). In some cases, anxiety is a secondary symptom to another, such as fatigue.

This appears to be the case in many women with breast cancer. Patients with breast cancer often report cancer-related fatigue (CRF). In some cases, CRF can lead to emotional distress and anxiety. One study of 48 patients found that Reishi promoted a better overall quality of life, including lower anxiety (29).

Reishi and Better Sleep

Sleep and anxiety have a two-way relationship. When you’re constantly feeling anxious, falling asleep can be a challenge. But lack of sleep can also impact your emotions, including anxiety. Reishi mushroom may be able to reduce the time it takes for you to fall asleep, thereby increasing your sleep time.

A mouse study suggests that reishi mushroom may impact a pathway associated with serotonin and gut bacteria (30). It also appears that reishi has GABAergic activity, the system responsible for regulating sleep (31). By promoting higher quality sleep, reishi may be able to soothe occasional anxiety and stress.

Reishi and Balanced Blood Sugar Levels

It may not be surprising to think that there’s a connection between nutrition and mental health. Several studies suggest improving your diet may help support a positive mood (32,33).

There is a possible link between blood sugar levels and mental health outcomes. Consumption of foods with a higher glycemic index is correlated with increased odds of anxiety and other mental disorders (34,35). Maintaining balanced blood sugar levels could help relieve occasional anxiety and stress. Decreasing the odds of high and low blood sugar is an important strategy when addressing potential triggers of anxiety.

Research suggests beta-glucans, like those from healthy mushrooms, may help keep your blood sugar levels steady (36).

A study with mice showed Reishi mushroom polysaccharides can regulate expressions of certain proteins associated with uncontrolled blood sugar levels. The polysaccharides also showed protective properties toward pancreatic beta-cells (37).

It’s important to note that most of the blood sugar research performed on functional mushrooms are animal or laboratory (cell) studies. So while many of the findings are promising, clinical trials will need to be conducted to confirm their benefits in humans.

Find out more about reishi in Reishi Mushroom Benefits & Usage: A Comprehensive Guide.

Lion’s Mane for Anxiety

When talking about functional mushrooms and neurological health, we can’t leave out Lion’s Mane.

The scientific name of Lion’s Mane mushroom, Hericium erinaceus, alludes to the two most well-studied compounds found in this species: hericenones and erinacines. Research studies suggest that these compounds in Lion’s Mane may improve brain function and protect against normal cognitive decline related to aging (38).

Let’s examine why some clinicians call Lion’s Mane the brain and nervous system mushroom (39).

Lion's mane for anxiety
Lion’s Mane is a functional mushroom known for supporting healthy brain function. It has compounds that are being studied for their potential effect on mood.

Lion’s Mane for Serotonin and Dopamine

Serotonin and dopamine, known as “happy hormones,” play key roles in your mood and appetite, among other things. In general, researchers believe that low levels of serotonin and dopamine are connected to anxiety and other mood disorders.

A 2018 study examined the effects of Lion’s Mane on stressed-out mice. The mice that weren’t given Lion’s Mane showed significant decreases in dopamine and serotonin after repeated exposures to stress. The reverse was seen in those that were given Lion’s Mane mushrooms (40).

The research team of the study also noted that the mice given Lion’s Mane had a healthier inflammatory response. The mice not given Lion’s Mane showed elevated levels of inflammation after stress exposure (40).

Scientists are still learning how Lion’s Mane impacts serotonin and dopamine levels. It’s possible that they are a result of the mushroom’s effects on your gut microbiome. The trillions of bacteria in your digestive tract produce a wide range of neurotransmitters, including dopamine and serotonin (41). Some research suggests they may have a role in anxiety and depression (42).

In 2017, Sheng and colleagues reported that the polysaccharides found in Lion’s Mane act in the intestines (43). Another study showed that a protein from Lion’s Mane could help regulate the gut microbiome composition (44). Traditionally, Lion’s Mane is used for digestive disorders and complaints, being a tonic for the organs responsible for digestion.

Lion’s Mane and Neurogenesis

Nerve growth factors (NGFs) and brain-derived neurotrophic factor (BDNF) play important roles in neurogenesis. In animals, changes in their levels are associated with neurodegeneration and psychiatric disorders (45,46,47,48). They also take part in brain plasticity (the ability to form new neural connections), particularly during development (49).

We don’t precisely know yet how NGF relates to health and disease. But studies on NGF deficiency have shown them to be correlated with anxiety-like behaviors in humans and animals. NGF-deficient mice exhibit increased anxiety, impaired spatial learning and memory, and decreased neurogenesis (50). In humans, reduced NGF levels have been observed in subjects with major depression, which is often linked to anxiety (51).

However, NGFs are unable to penetrate the blood-brain barrier without help (52).

This is where Lion’s Mane comes in. Both hericenones and erinacines easily cross the blood-brain barrier. Laboratory and animal studies also show they have qualities that protect your neurons and nerves. They are also able to enhance NGF activity (38,53).

Isoindolinones are unique, lesser-known neurotrophic compounds found in Lion’s Mane mushrooms.The isoindolinone derivative isohericerinol A found in Lion’s mane has been shown to increase neurite outgrowth via NGF synthesis and BDNF upregulation. Isohericerinol A joins the existing compounds known to induce NGF and modulate BDNF at an in-vitro level. These other existing compounds include: corallocin A, hericerin, hericenones and erinacines (67).

Studies on Lion’s Mane for Mood

A 2018 mouse study suggested encouraging hippocampal neurogenesis could have mood-enhancing effects. The mice given Lion’s Mane mushroom extracts showed less anxiety and improved mood during their assessments (54).

Evidence from human clinical trials lends support to this hypothesis as well. In a 2010 study, 26 patients were asked to eat 4 cookies per day containing either Lion’s Mane mushroom or placebo. Those taking Lion’s Mane scored lower on several measures, including an anxiety score (55).

Another trial assessed whether a mixture of Lion's Mane mushroom and mycelium could improve mood in patients with obesity or who are overweight. At the end of the 8-week trial, the overweight participants in this study who received Lion’s Mane reported significant improvements in their mood. They also had higher circulating pro-BDNF, a BDNF precursor. These findings suggest that BDNF could be a biomarker for mood disorders (56).

Interested in learning more about Lion’s Mane? Check out Lion’s Mane Mushroom Benefits: A Complete Supplement Guide.

Cordyceps for Anxiety

Cordyceps are a group of mushrooms that include over 400 different species. The two most well-known species are Cordyceps sinensis and Cordyceps militaris.

In TCM, Cordyceps mushrooms were used to strengthen the lungs and kidneys. It was also used to enhance sexual function and libido.

Cordyceps may also have potential for boosting your mood. Preliminary human and animal studies suggest Cordyceps help support a healthy inflammation response (57,58,59,60). In theory, a healthy inflammation response may help alleviate occasional anxiety and stress.

Animal research suggests cordyceps mushrooms can help keep blood sugar levels steady (61). This effect appears to support a positive mood in mice (62). Further evidence will be needed to confirm the benefits in humans.

Other animal research suggests Cordyceps may act on stress-related pathways in the brain. A 2021 publication reported that rats given Cordyceps didn’t show abnormal behavior from stress exposure (63). Another report presented evidence that Cordyceps might act on important protein targets and their signaling pathways. The research team suggested the regulation of these targets and their pathways could support mood stability (64).

Cordyceps mushrooms for anxiety
Cordyceps mushrooms have a balancing effect on a number of systems in the body such as the gut microbiome and certain brain signal pathways. When taking this mushroom as a supplement, the downline effect can be a balanced mood.

Cordyceps may help counter oxidative stress caused by anxiety and stress. Cell studies showed increased survival under stress when a Cordyceps treatment was applied (65). Cordyceps may also help balance circadian rhythms due to a unique compound called cordycepin. A mouse study showed a 60% improvement in jet lag recovery when using cordycepin. Therefore, using cordyceps extracts may help address the impact of social jet lag (lack of sleep) on anxiety and overall well-being (68).

Ready to learn more about Cordyceps mushrooms? Read our comprehensive guide, Cordyceps Mushrooms: Supplement Types & Health Benefits.

How to Use Mushrooms for Anxiety

It’s a good idea to take functional mushrooms long-term to experience the benefits they have to offer for anxiety. Three months is the minimum recommended amount of time to give a new supplement regime a chance to work.

But it’s also important to ensure that you’re only consuming those supplements that are of the highest quality. What does this mean?

When buying a mushroom supplement, make sure that it is actually made from the mushroom (fruiting body). The mushroom is where you can find an abundance of beneficial compounds like beta-glucans.

Avoid products made of mycelium since this fungal “root system” is commonly grown on a grain substrate and this grain is not fully consumed by the mycelium and ends up in the final product. Therefore, the end product has diluted medicinal value and undesirable grain fillers. To learn more, check out our article Medicinal Mushroom Benefits: Mycelium vs. Fruiting Body.

Ensuring high quality is especially important when it comes to Reishi. A 2017 article published in the journal Nature raised alarm about Reishi mushrooms. In this study, only 5 out of the 19 reishi mushroom samples, 26%, actually contained what was on their labels (66). That means a whopping 74% of the “reishi” supplements didn’t contain authentic Reishi.

At Real Mushrooms, we take pride in our sourcing and extraction methods for our functional mushroom products. Our products are guaranteed to contain no fillers, starch, or grains. This is all so that you can experience the most benefits from functional mushrooms.

Learn more by reading our articles on Reishi, Lion’s Mane, and Cordyceps.

5 Recipes With Mushrooms for Anxiety

Here are some convenient and creative recipes for our Reishi 415, Lion’s Mane, and Cordyceps powdered extracts. You can add the mushroom powder to your coffee, tea, or one of the following healthful recipes. Alternatively, you can simply take your mushroom supplement in capsule form.

  1. Nourishing Mushroom Elixir

Help kickstart your immune system into gear and support a healthy inflammation response. This mushroom elixir features our Reishi, Lion’s Mane, and Cordyceps extracts.

Lion's mane recipe - donut holes
Healthy indulgences like these baked keto donut holes with lion’s mane extract can be a delicious and comforting way to get your functional mushrooms without spiking your blood sugar levels.
  1. Keto Baked Donuts

“Healthy” doesn’t exactly come to mind when we think of donuts. But what if they could be? Our keto baked donuts with Lion's Mane extract are a great way to excite your taste buds and reduce stress and anxiety.

Golden milk with functional mushrooms
Golden milk with lion’s mane and ashwagandha will give you the balancing effects of these two powerful adaptogens. It’s a great way to start the day off with a calmed system.
  1. Morning Golden Milk

Skip the coffee and prepare your brain for the day with our morning golden milk instead. The combination of lion’s mane, ashwagandha, and others will keep you coming back for more.

  1. Evening Vegan Mushroom Golden Milk

Honestly, what’s better than sipping a warm, soothing golden milk while you sit back and relax after a long day? Reishi can help your body adapt to stress and improve your sleep. Try it in our evening golden milk recipe.

  1. Snicker Doodle Ice Cream Shake

Yes, you read that right. Healthy shouldn’t mean tasteless and we’re big fans of tasty foods. When your anxiety makes you want to stay in, try some self-care with this goodie. This ice cream shake features our Lion’s Mane and Cordyceps extracts.

Ease Occasional Anxiety With Mushrooms

Anxiety can make you feel like you’re losing control of yourself. A healthy lifestyle that incorporates functional mushrooms may be able to help reduce occasional anxiety. If you experience severe anxiety, it’s important to seek professional help.

If you’re looking for the best mushrooms for anxiety, we recommend Reishi, Lion’s Mane, and Cordyceps.

Real Mushrooms is confident in the safety and efficacy of our products. We recommend that you consult your physician before starting any new supplement.

Lion's mane mushroom capsules for anxiety
Consider taking a high quality mushroom supplement as a natural support for your mood.


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